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Regular version of the site

Laboratory of Molecular Physiology

Publications
Article
Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies

Knyazev E., Vishnyakova P., Lazareva O. et al.

Biochip Journal. 2025.

Working paper
Type of Physical Activity, Diet, BMI and Tobacco/Alcohol Consumption Relationship: How They are Associated with Our Health

Люцко Л. Н., Веракса А. Н., Polikanova I. et al.

MDPI Preprints. 2021030766. MDPI, 2021. No. 2021030766.

The laboratory specializes in investigating the molecular physiology of human tumors and organs, exploring both normal and pathological conditions. Leveraging cutting-edge microfluidic technologies, alongside molecular genetics and bioinformatics methodologies, our research aims to elucidate the specific roles played by individual genes and microRNA molecules or their isoforms in the pathogenesis of diverse diseases and pathological states.

News

In the article “Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies,” Russian scientists have presented an overview of modern cellular models of preeclampsia—a dangerous pregnancy complication. The study covers two-dimensional and three-dimensional cultures, as well as advanced placenta-on-a-chip microfluidic technologies, allowing the examination of pathological mechanisms at the cellular level. The paper highlights the potential of CRISPR-Cas9 and personalized models for developing new diagnostic and therapeutic methods for preeclampsia. These advancements open prospects for more precise early diagnosis of preeclampsia and the creation of effective treatment strategies.
February 04
The Moscow Young Scientists Club was established as part of the "At the Center of Science" project, organized by the Center for Pedagogical Excellence with funding from the Moscow Department of Education and Science.
January 09
This project, organized by the Moscow Department of Education and Science with the support of the Center for Pedagogical Excellence and other institutions, includes lectures, workshops, and educational intensives featuring science communicators and leading scientists from across Russia.
December 05, 2024
During the session “Microfluidic Technologies: Will Organ-on-Chip Replace In Vivo Studies?”, Evgeny Knyazev presented the laboratory’s research projects, including:
Development of an in vitro intestine-on-a-chip model with physiologic permeability characteristics;
RSF grant project: Microfluidic placenta-on-a-chip model for the study of preeclampsia.
November 27, 2024
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