Faculty of Biology and Biotechnology

Publications

• Book

  Alshanskaia Sokolova E. I., Martynova O.

  2023 Fifth International Conference Neurotechnologies and Neurointerfaces (CNN) 18-20 Sept. 2023

   Cognitive and emotional load in the course of increasing the complexity of tasks leads to the activation of various parts of the autonomic nervous system (ANS) and can be accompanied by an increase in the efficiency of problem solving. An increase in cognitive load under the condition of high motivation is a stress factor and is expressed in a different reaction of the sympathetic and parasympathetic links in response to the load. This study explored the ANS reactions by measuring the pupil size of 61 healthy sub-clinical volunteers in response to the gradually increasing complexity of tasks. The experiment included 3 blocks of a combined visual search and 1-back task with six levels of difficulty. K-mean clustering method was used for the analysis. An increase in the complexity of the task from the first to the sixth level led to different dynamics of the pupil size in the three clustered groups. In one group, an intense high switchability and an active reaction with a large amplitude of changes were visible, in the second group the dynamics of changes was minimal, and a third intermediate group was also identified. Our results highlight individual differences in the reaction of the sympathetic and parasympathetic branches of ANS under cognitive workload depending on biometric and psychometric parameters. 

  IEEE, 2023.

• Article

  Kolodeeva O., Kolodeeva O., Averinskaya D. et al.

  Induction of the PERK-eIF2α-ATF4 Pathway in M1 Macrophages under Endoplasmic Reticulum Stress

  Translation inhibition can activate two cell death pathways. The first pathway is activated by trans-lational aberrations, the second by endoplasmic reticulum (ER) stress. In this work, the effect of ribosome-inactivating protein type II (RIP-II) viscumin on M1 macrophages derived from the THP-1 cell line wasinvestigated. The number of modified ribosomes was evaluated by real-time PCR. Transcriptome analysisrevealed that viscumin induces the ER stress activated by the PERK sensor.

  Doklady Biochemistry and Biophysics. 2024. Vol. 517. No. 1. P. 264-268.

• Book chapter

  Okhrimenko G., Malko D., Zateyshchikov D. et al.

  Detection of non-coding variants in regulatory elements in patients with early atherosclerosis based on whole genome sequencing data

  In bk.: Proceedings of 11th Moscow Conference on Computational Molecular Biology MCCMB'23. IITP RAS, 2023.

• Working paper

  Liutsko L., Malova Y., Vinokurova E. et al.

  Stress Resilience (Proprioceptive and Verbal Individual Differences) in Onco-Patients, Sportsmen and Controls

  The characteristics of response to stressful situations depend on a complex of factors such as personality traits, emotional regulation, health state, features of the nervous system, motor functions and proprioception. In cases of disruption of the brain's dopamine system due to disease or chemotherapy, hormone discharge due to stress, changes in emotions and proprioception may occur. The aim of our study was to find the relationship of stress resilence in verbal test and individual differences performed in proprioceptive test in onco-patients, sportsmen and group of control; as well as to observe the differences between these groups in the verbal stress resistance and individual differences proprioceptive tests. The results showed that onco-patients were less resistant as per verbal stress resistance outcomes for a major part of variables compared to other groups. The sportsmen were superior in verbal Risk and Control dimensions compared to other groups; but less in Positive Affectiveness. The proprioceptive test perfomance revealed the only statistically significant difference in performance in the dimension related to Mood, showing more Pessimism in the sportsmen group, but more Optimism in the oncopatients at temperamental (or intrisinc) level. The obtained results can be used by psychologists, therapists, coach and healthcare when needed to attend the specific needs of public, being pateints or sportsmen, etc.

  public health and health services. 20944. MDPI, 2023