Laboratory for Research on Molecular Mechanisms of Longevity

Publications

Article

ELOVL5 and IGFBP6 genes modulate sensitivity of breast cancer cells to ferroptosis

Nikulin S., Razumovskaya A., Poloznikov A. et al.

Frontiers in Molecular Biosciences. 2023. Vol. 10.

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The laboratory conducts research activities in the field of molecular mechanisms of longevity.

Considerable attention in the Laboratory activities is given to sequencing of mRNA, microRNA and assessment of gene methylation. New methodological approaches are being developed for bioinformatic analysis of experimental results, which use mRNA/microRNA sequencing data and graph analysis.

As a part of the Laboratory's work, it is planned to implement a unique approach to influence a controlled multi-organ model with physiological concentrations of metabolites of the intestinal microflora and extracellular vesicles produced by cells of the immune system.

We maintain partnership with the Institute of Bioorganic Chemistry. Academician M.M. Shemyakin and Yu.A. Ovchinnikov RAS, Nizhny Novgorod State University. N.I. Lobachevsky, Scientific Center for Family Health and Human Reproduction.

News

Intestinal microRNAs influence the evolution of the SARS-CoV-2 genome

April 11

Lab staff publication included in authoritative IEDB Validated Epitope Database

Research & Expertise publications research projects achievements

March 02

Evolution of the SARS-CoV-2

As part of the study, researchers of the Laboratory for Research on Molecular Mechanisms of Longevity was able to demonstrate that microRNAs in human lung tissue exert evolutionary pressure on the SARS-CoV-2 genome.

Research & Expertise

December 08, 2022

A series of seminars and practical classes of the Laboratory «Methods of tissue engineering using click chemistry»

From October 17 to 28, 2022 a series of seminars and workshops led by Dmitri Rogozhnikov took place at the Research on Molecular Mechanisms of Longevity.

Research & Expertise innovations

November 01, 2022

COVID-19 T-Cell Atlas: HSE Researchers Develop a Comprehensive Web Portal

Laboratory for Research on Molecular Mechanisms of longevity, in collaboration with other departments of the Faculty of Biology and Biotechnology (HSE University), developed the COVID-19 T-cell atlas - a comprehensive web portal, which allows to analyze how SARS-CoV-2 mutations change the presentation of viral peptides.

September 06, 2022

Seminar of the Laboratory 'Biology of the SARS-CoV-2 virus'

At the meeting of the seminar, a student of the 3rd year of study of the bachelor's program 'Cellular and Molecular Biotechnology' Fedor Polyakov reviewed the article Kim D et al. A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome. Nat Commun. 2021 Aug 25;12(1):5120 (doi: 10.1038/s41467-021-25361-5).

Research & Expertise

February 25, 2022

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