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Regular version of the site

Laboratory for Research on Molecular Mechanisms of Longevity

Publications
Article
Challenges in Characterization of Transcriptomes of Extracellular Vesicles and Non-Vesicular Extracellular RNA Carriers

Makarova J., Maltseva D., Tonevitsky A.

Frontiers in Molecular Biosciences. 2023. Vol. 10.

Working paper
Is Frequency of Practice of Different Types of Physical Activity Associated with Health and a Healthy Lifestyle at Different Ages?

Люцко Л., Леонов С. В., Пащенко А. et al.

physical therapy, sports therapy and rehabilitation. 2023102018. MDPI Preprints, 2023

The laboratory conducts research activities in the field of molecular mechanisms of longevity.

Considerable attention in the Laboratory activities is given to sequencing of mRNA, microRNA and assessment of gene methylation. New methodological approaches are being developed for bioinformatic analysis of experimental results, which use mRNA/microRNA sequencing data and graph analysis.

As a part of the Laboratory's work, it is planned to implement a unique approach to influence a controlled multi-organ model with physiological concentrations of metabolites of the intestinal microflora and extracellular vesicles produced by cells of the immune system.

We maintain partnership with the Institute of Bioorganic Chemistry. Academician M.M. Shemyakin and Yu.A. Ovchinnikov RAS, Nizhny Novgorod State University. N.I. Lobachevsky, Scientific Center for Family Health and Human Reproduction.

News

Hemophagocytic syndrome and macrophages

A seminar dedicated to the study of the molecular biological aspects of the occurrence of hemophagocytic syndrome (HFS) was held in the Laboratory for Research on Molecular Mechanisms of Longevity.

Scientific Seminar:“The Relationship between IGFBP6 Gene Expression and the Rate of Exosome Secretion by MDA-MB-231 Cells”

Intestinal microRNAs influence the evolution of the SARS-CoV-2 genome

Lab staff publication included in authoritative IEDB Validated Epitope Database

Evolution of the SARS-CoV-2

As part of the study, researchers of the Laboratory for Research on Molecular Mechanisms of Longevity was able to demonstrate that microRNAs in human lung tissue exert evolutionary pressure on the SARS-CoV-2 genome.

A series of seminars and practical classes of the Laboratory «Methods of tissue engineering using click chemistry»

From October 17 to 28, 2022 a series of seminars and workshops led by Dmitri Rogozhnikov took place at the Research on Molecular Mechanisms of Longevity.

COVID-19 T-Cell Atlas: HSE Researchers Develop a Comprehensive Web Portal

Laboratory for Research on Molecular Mechanisms of longevity, in collaboration with other departments of the Faculty of Biology and Biotechnology (HSE University), developed the COVID-19 T-cell atlas - a comprehensive web portal, which allows to analyze how SARS-CoV-2 mutations change the presentation of viral peptides.

Seminar of the Laboratory 'Biology of the SARS-CoV-2 virus'

At the meeting of the seminar, a student of the 3rd year of study of the bachelor's program 'Cellular and Molecular Biotechnology' Fedor Polyakov reviewed the article Kim D et al. A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome. Nat Commun. 2021 Aug 25;12(1):5120 (doi: 10.1038/s41467-021-25361-5).

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