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Laboratory for Research on Molecular Mechanisms of Longevity

Publications
Article
Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

Nersisyan S., Zhiyanov A., Zakharova M. et al.

PeerJ. 2022. Vol. 10.

The laboratory conducts research activities in the field of molecular mechanisms of longevity.

Considerable attention in the Laboratory activities is given to sequencing of mRNA, microRNA and assessment of gene methylation. New methodological approaches are being developed for bioinformatic analysis of experimental results, which use mRNA/microRNA sequencing data and graph analysis.

As a part of the Laboratory's work, it is planned to implement a unique approach to influence a controlled multi-organ model with physiological concentrations of metabolites of the intestinal microflora and extracellular vesicles produced by cells of the immune system.

We maintain partnership with the Institute of Bioorganic Chemistry. Academician M.M. Shemyakin and Yu.A. Ovchinnikov RAS, Nizhny Novgorod State University. N.I. Lobachevsky, Scientific Center for Family Health and Human Reproduction.

News

COVID-19 T-Cell Atlas: HSE Researchers Develop a Comprehensive Web Portal

Laboratory for Research on Molecular Mechanisms of longevity, in collaboration with other departments of the Faculty of Biology and Biotechnology (HSE University), developed the COVID-19 T-cell atlas - a comprehensive web portal, which allows to analyze how SARS-CoV-2 mutations change the presentation of viral peptides.

Seminar of the Laboratory «Biology of the SARS-CoV-2 virus»

At the meeting of the seminar, a student of the 3rd year of study of the bachelor's program "Cellular and Molecular Biotechnology" Fedor Polyakov reviewed the article Kim D et al. A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome. Nat Commun. 2021 Aug 25;12(1):5120 (doi: 10.1038/s41467-021-25361-5).

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