Scientific Seminar:“The Relationship between IGFBP6 Gene Expression and the Rate of Exosome Secretion by MDA-MB-231 Cells”

In the Laboratory for Research on Molecular Mechanisms of Longevity, a seminar was held on the relationship between IGFBP6 gene expression and the rate of exosome secretion by breast cancer (BC) cells MDA-MB-231. The results obtained by students of the master's educational program "Cellular and Molecular Biotechnology" A. Efimova and I. Antipenko were discussed.


The importance of exosomes in the development and progression of tumors, in particular breast cancer, was previously demonstrated. Tumor exosomes from breast cancer cells can promote the activation of NF-κB and the secretion of pro-inflammatory cytokines such as IL-6, TNF-α, GCSF and CCL2 by macrophages, inducing pro-inflammatory activity necessary for the evasion of tumor cells from immune “surveillance” during tumorigenesis.


Proteins and microRNAs regulating apoptosis, cytoskeletal remodeling, cell cycle, tumor invasion and metastasis were identified for exosomes isolated from the breast cancer cell line MDA-MB-231. In addition, recent studies have shown that exosomes containing miR-10b and miR-21 provide enhanced viability, proliferation, and colony-forming ability of cancer cells.


The results of the seminar will be used in preparing a publication based on the results of the work.