The laboratory is developing a new method of personalized drug therapy for cancer patients, which includes establishment of a three-dimensional culture of tumor organoids, followed by a personalized test of chemotherapeutic and targeted drugs to determine the most effective therapy for each individual patient.
We maintain cooperation with National Medical Research Radiological Center, Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Scientific and Technical Center BioClinicum and University Medical Center Hamburg-Eppendorf.
Higher School of Economics (NRU HSE) researchers with colleagues from the Far Eastern Federal University (FEFU) are creating a test system to study the toxicity of drugs and their permeability through the intestines. Universities equally finance joint research projects within the framework of the Mirror Laboratories competition, initiated by the Higher School of Economics
International Laboratory of Microphysiological Systems of the National Research University Higher School of Economics staff with their colleagues from the Laboratory of Microphysiological Systems from FEFU are going to create an innovative microfluidic test platform "intestines on a chip". With the use of this platform, scientists propose to study in real time the interaction of biologically active molecules with intestinal tissues and assess the toxicity and permeability of drugs through the barrier tissue of the small intestine. Due to this development, it would be possible to move away from ethically questionable and resource-intensive drug testing on animals and humans.
Members of the International Laboratory of Microphysiological Systems and students of the Faculty of Biology and Biotechnology gave an interview to the correspondent of “MIR” TV company on the results of their study of molecules capable to suppress the replication of coronaviruses
Faculty of Biology and Biotechnology researchers in their interview to the correspondent of «MIR» TV company talked about their study on interactions between microRNA molecules and human coronaviruses.
Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal.
This June, first-year undergraduate students of the HSE Faculty of Biology and Biotechnology took part in an online seminar at George Mason University (USA). The seminar was part of the Coronavirus Research Update summer course, taught by Professor Ancha Baranova.
Article "The role of regulation of APF2 / TMPRSS2 genes by intestinal miRNA isoforms in the pathogenesis of COVID-19" is published in the Scientific Medical Journal of the Russian National Research Medical University named after N.I. Pirogova
Article is published by Stepan Nersisyan, Fellow at the International Laboratory for Microphysiological Systems of HSE
Article "Biology-inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development" is published in ALTEX
Joint scientific work is published by Alexander Tonevitsky, the Dean of Faculty of Biology and Biotechnology of the Higher School of Economics and foreign colleagues
The International Laboratory of Microphysiological Systems is created at the Faculty of Biology and Biotechnology of the Higher School of Economics