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Regular version of the site

International Laboratory of Microphysiological Systems

Publications
Article
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2

Nersisyan S., Shkurnikov M., Turchinovich A. et al.

Plos One. 2020. Vol. 15. No. 7. P. e0235987.

Article
Enzyme Release from Polyion Complex by Extremely Low Frequency Magnetic Field

Vlasova K., Vishwasrao H., Abakumov M. et al.

Scientific Reports. 2020. Vol. 10. P. 4745.

Article
Роль регуляции генов AПФ2/TMPRSS2 изоформами микроРНК кишечника в патогенезе COVID-19

Нерсисян С. А., Шкурников М. Ю., Осипьянц А. И. и др.

Вестник Российского государственного медицинского университета. 2020. № 2. С. 17-20.

Article
A post-processing algorithm for miRNA microarray data

Nersisyan S., Shkurnikov M., Poloznikov A. et al.

International Journal of Molecular Sciences. 2020. Vol. 21. No. 4. P. 1228.

The laboratory is developing a new method of personalized drug therapy for cancer patients, which includes establishment of a three-dimensional culture of tumor organoids, followed by a personalized test of chemotherapeutic and targeted drugs to determine the most effective therapy for each individual patient.

We maintain cooperation with National Medical Research Radiological Center, Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Scientific and Technical Center BioClinicum and University Medical Center Hamburg-Eppendorf.


Illustration for news: Researchers Find Therapeutic Targets to Fight SARS-CoV-2

Researchers Find Therapeutic Targets to Fight SARS-CoV-2

Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal.

Illustration for news: Joint Seminar of HSE Faculty of Biology and Biotechnology and George Mason University

Joint Seminar of HSE Faculty of Biology and Biotechnology and George Mason University

This June, first-year undergraduate students of the HSE Faculty of Biology and Biotechnology took part in an online seminar at George Mason University (USA). The seminar was part of the Coronavirus Research Update summer course, taught by Professor Ancha Baranova.

Illustration for news: Article "The role of regulation of APF2 / TMPRSS2 genes by intestinal miRNA isoforms in the pathogenesis of COVID-19" is published in the Scientific Medical Journal of the Russian National Research Medical University named after N.I. Pirogova

Article "The role of regulation of APF2 / TMPRSS2 genes by intestinal miRNA isoforms in the pathogenesis of COVID-19" is published in the Scientific Medical Journal of the Russian National Research Medical University named after N.I. Pirogova

Article is published by Stepan Nersisyan, Fellow at the International Laboratory for Microphysiological Systems of HSE

Article "Biology-inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development" is published in ALTEX

Joint scientific work is published by Alexander Tonevitsky, the Dean of Faculty of Biology and Biotechnology of the Higher School of Economics and foreign colleagues

March 16, 2020 the opening of the International Laboratory of Microphysiological Systems

The International Laboratory of Microphysiological Systems is created at the Faculty of Biology and Biotechnology of the Higher School of Economics