The laboratory is developing a new method of personalized drug therapy for cancer patients, which includes establishment of a three-dimensional culture of tumor organoids, followed by a personalized test of chemotherapeutic and targeted drugs to determine the most effective therapy for each individual patient.
We maintain cooperation with National Medical Research Radiological Center, Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Scientific and Technical Center BioClinicum and University Medical Center Hamburg-Eppendorf.
Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE journal.
This June, first-year undergraduate students of the HSE Faculty of Biology and Biotechnology took part in an online seminar at George Mason University (USA). The seminar was part of the Coronavirus Research Update summer course, taught by Professor Ancha Baranova.
Article "The role of regulation of APF2 / TMPRSS2 genes by intestinal miRNA isoforms in the pathogenesis of COVID-19" is published in the Scientific Medical Journal of the Russian National Research Medical University named after N.I. Pirogova
Article is published by Stepan Nersisyan, Fellow at the International Laboratory for Microphysiological Systems of HSE
Article "Biology-inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development" is published in ALTEX
Joint scientific work is published by Alexander Tonevitsky, the Dean of Faculty of Biology and Biotechnology of the Higher School of Economics and foreign colleagues
The International Laboratory of Microphysiological Systems is created at the Faculty of Biology and Biotechnology of the Higher School of Economics