A press release has been published on the atypical synergistic effect of miR-93-5p microRNA isoforms in prostate cancer
A press release has been released on the HSE website (https://www.hse.ru/news/science/1152167635.html) based on an article about the unique properties of miR-93-5p microRNA (published in the journal PeerJ https://peerj.com/articles/20642/). HSE researchers have discovered an atypical behavior of oncogenic miR-93-5p microRNA in prostate cancer. It turned out that its various isoforms do not change the spectrum of target genes, but rather enhance each other's effects.
%20(1).png "The uniqueness of miR-93-5p microRNAs")
The uniqueness of miR-93-5p microRNAs
miR-93-5p microRNA in prostate cancer retains a similar set of targets even with the formation of 5’ isoforms. This indicates the stability of its regulatory function to structural variations.
%20(4).jpg "MicroRNAs Are Involved in Regulating Colorectal Cancer Metastasis via the CD44 Receptor")
MicroRNAs Are Involved in Regulating Colorectal Cancer Metastasis via the CD44 Receptor
Knockdown of CD44 in colorectal cancer tumours alters the expression of microRNAs and their targets involved in epithelial–mesenchymal transition and the Notch signalling pathway, both of which are associated with tumour metastasis