The laboratory is developing a new method of personalized drug therapy for cancer patients, which includes establishment of a three-dimensional culture of tumor organoids, followed by a personalized test of chemotherapeutic and targeted drugs to determine the most effective therapy for each individual patient.
We maintain cooperation with National Medical Research Radiological Center, Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Scientific and Technical Center BioClinicum and University Medical Center Hamburg-Eppendorf.
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The International Laboratory of Microphysiological Systems has implemented an automated system for preparing polyacrylamide gels of various compositions, as well as a robotic workstation for immunoblotting, into its research workflow
Researchers from the International Laboratory of Microphysiological Systems have presented a review devoted to single‑cell analysis of colorectal cancer. The article systematises current data obtained using single‑cell RNA‑sequencing technologies, with a particular focus on the fundamental differences between left‑ and right‑sided tumours
Diana Vasilievna spoke about the laboratory's work to Vyshka.Glavnoe
An employee of the International Laboratory of Microphysiological Systems took part in the International Conference for Young Scientists “Genetic Technologies in Biomedicine”
The International Laboratory of Microphysiological Systems is pleased to share an interview given by junior research fellow Maria Yanova as part of the “Young Scientists” project. In this inspiring piece, Maria tells her own story in science
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Knockdown of CD44 in colorectal cancer tumours alters the expression of microRNAs and their targets involved in epithelial–mesenchymal transition and the Notch signalling pathway, both of which are associated with tumour metastasis
Three poster presentations were presented with the latest data of scientific research conducted in the laboratory
The Congress was held from 11-15 August 2024 in Maastricht, the Netherlands
The conference was held on 11 July 2024
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Our results show that the design of shRNA affects its processing by RNase-III Dicer and can result in the generation of undesirable 5'-isoforms of miRNA/siRNA encoded within the shRNA. This effect is especially significant for miRNA/siRNA longer than 19 nt.