The laboratory is developing a new method of personalized drug therapy for cancer patients, which includes establishment of a three-dimensional culture of tumor organoids, followed by a personalized test of chemotherapeutic and targeted drugs to determine the most effective therapy for each individual patient.
We maintain cooperation with National Medical Research Radiological Center, Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Scientific and Technical Center BioClinicum and University Medical Center Hamburg-Eppendorf.
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Our results show that the design of shRNA affects its processing by RNase-III Dicer and can result in the generation of undesirable 5'-isoforms of miRNA/siRNA encoded within the shRNA. This effect is especially significant for miRNA/siRNA longer than 19 nt.
Article describes mechanisms the CD44 alternative splicing
20 марта 2023 г. в рамках конференции «Наукоемкие лабораторные технологии для клинической практики» на секции, посвященной опухолевым маркерам сотрудница Международной лаборатории микрофизиологических систем Мария Янова выступила с докладом «Маркеры эффективности химиотерапии с использованием гемцитабина у больных раком мочевого пузыря».
Researchers from the Faculty of Biology and Biotechnology at the Higher School of Economics conducted a joint study with colleagues from National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Center for Digital Biodesign and Personalized Health Care (Sechenov University) and Institute of Bioorganic Chemistry of the Russian Academy of Sciences, dedicated to the study of the link between low expression of the IGFBP6, ELOVL5 genes and lipid metabolism in breast cancer cells. The results of the study will be published in the journal Frontiers in Molecular Biosciences.
The International Laboratory of Microphysiological Systems held an online conference with international participation: 'Bioinformatics and biomedicine' on October 19, 2022 and 'Tumor metastasis: mechanisms, key stages, modeling research' on November 25, 2022
Researchers of the International Laboratory of Microphysiological Systems of the Faculty of Biology and Biotechnology (HSE University), in collaboration with the Laboratory of Molecular Physiology of the Faculty of Biology and Biotechnology (HSE University), as well as German colleagues from the Institute of Anatomy and Experimental Morphology (Hamburg) and the Institute of Pathology (Göttingen), found an association between low expression of the CD24 protein in patients with colorectal cancer and a decrease in patient survival rate.
An article by the staff of the International Laboratory of Microphysiological Systems and collaborators from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences 'Specificity of viscumin revised. As probed with a printed glycan array' accepted for publishing in Biochimie journal.
On June 24, 2022, the International Laboratory of Microphysiological Systems hosted a joint seminar with the Laboratory for Research on the Molecular Mechanisms of Longevity, dedicated to the issue of miRNA overexpression in human cells, a process that leads to an excess amount of transcript produced by the genome.
The competition is open to HSE University research units planning to conduct joint projects with academic institutions, research organisations and state academic centres of the Russian Federation. Applications are open until May 20, 2022.
Two international laboratories will be created at the HSE University Institute of Electronics and Mathematics, one at the Faculty of Geography and Geoinformation Technology, and one at the Faculty of Biology and Biotechnology. The four projects were selected from a total of 17 applications.