The laboratory is developing a new method of personalized drug therapy for cancer patients, which includes establishment of a three-dimensional culture of tumor organoids, followed by a personalized test of chemotherapeutic and targeted drugs to determine the most effective therapy for each individual patient.
We maintain cooperation with National Medical Research Radiological Center, Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS, Scientific and Technical Center BioClinicum and University Medical Center Hamburg-Eppendorf.
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Three poster presentations were presented with the latest data of scientific research conducted in the laboratory
The Congress was held from 11-15 August 2024 in Maastricht, the Netherlands
The conference was held on 11 July 2024
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Our results show that the design of shRNA affects its processing by RNase-III Dicer and can result in the generation of undesirable 5'-isoforms of miRNA/siRNA encoded within the shRNA. This effect is especially significant for miRNA/siRNA longer than 19 nt.
The International Microphysiological Systems Laboratory announces recruitment of research interns among undergraduate and graduate students of the Faculty of Biology and Biotechnology of the National Research University Higher School of Economics on a competitive basis for the year 2024
Researchers have established a link between forms of the CD44 protein and the severity of colorectal cancer progression.
Article describes mechanisms the CD44 alternative splicing
20 марта 2023 г. в рамках конференции «Наукоемкие лабораторные технологии для клинической практики» на секции, посвященной опухолевым маркерам сотрудница Международной лаборатории микрофизиологических систем Мария Янова выступила с докладом «Маркеры эффективности химиотерапии с использованием гемцитабина у больных раком мочевого пузыря».
Researchers from the Faculty of Biology and Biotechnology at the Higher School of Economics conducted a joint study with colleagues from National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Center for Digital Biodesign and Personalized Health Care (Sechenov University) and Institute of Bioorganic Chemistry of the Russian Academy of Sciences, dedicated to the study of the link between low expression of the IGFBP6, ELOVL5 genes and lipid metabolism in breast cancer cells. The results of the study will be published in the journal Frontiers in Molecular Biosciences.
The International Laboratory of Microphysiological Systems held an online conference with international participation: 'Bioinformatics and biomedicine' on October 19, 2022 and 'Tumor metastasis: mechanisms, key stages, modeling research' on November 25, 2022