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Laboratory of Molecular Physiology

Established in 2020, the Laboratory of Molecular Physiology studies the role of microRNA isoforms in the pathogenesis of intestinal diseases and develops new therapeutic approaches to intestinal condition treatment using microRNA isoforms. We collaborate with the National Medical Research Radiological Center, the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, and University Medical Center Hamburg-Eppendorf.

The Laboratory was created to further priority areas of scientific research of the Faculty of Biology and Biotechnology in the field of molecular physiology, which are urgently needed for the development of a modern high-tech methods of diagnostics, prevention, and monitoring of treatment of various diseases in the transition to personalized medicine.

News

Members of the International Laboratory of Microphysiological Systems took part in SIBS-2021

The 5th Sechenov International Biomedical Summit (SIBS - 2021) was held on November 9-10, 2021 at FSAU VO Sechenov Russian Ministry of Health (Sechenov University). It is one of the most authoritative forums in the country in the field of advanced bioengineering, regenerative and personalized medicine.

Members of the International Laboratory of Microphysiological Systems and the Laboratory of Molecular Physiology participated in RECOMB 2021

25th International Conference on Research in Computational Molecular Biology (RECOMB 2021) was held online on August 29th - September 2nd. Staff of the Faculty of Biology and Biotechnology - Stepan Nersisyan, Alexey Galatenko, Diana Maltseva and Alexander Tonevitsky participated in a poster session with the report «miRGTF-net: Integrative miRNA-gene-TF network analysis reveals key drivers of breast cancer recurrence»

The International Laboratory of Microphysiological Systems at the 11th World Congress on Alternatives and Uses of Animals in Natural Sciences (WC11)

Alexander G. Tonevitsky, Leading Research Fellow of the International Laboratory of Microphysiological Systems, took part at the 11th World Congress on Alternatives and Use of Animals in Natural Sciences (WC11)

Russian Scientists Investigate the Immune Response to SARS-CoV-2 Variants

HSE University researchers assessed the effectiveness of the T-cell immune response to 11 variants of SARS-CoV-2. Their findings have been published in Nucleic Acids Research.

Hormones Can Help Brain Recover after Injury

An international team of researchers including Alexander Tonevitsky, Professor at HSE’s Faculty of Biology and Biotechnology, found that pituitary hormones may produce different effects on the left and right sides of the body following a traumatic brain injury. These differences can accelerate the development of motor disorders. Researchers are trying to determine whether treatment that blocks the corresponding hormones can counteract these effects. The results of the study were published in the journal eLife.

HSE Researchers Discover Nucleotide Sequence Responsible for Effectively Fighting Pathologies

Researchers from HSE University have discovered nucleotide sequences characteristic of microRNA isoforms (microRNAs with errors). The discovery will help predict errors in microRNA behaviour and create drugs that can detect targets (such as viruses) more effectively. The results of the study have been published in the RNA Biology journal.

The New RSCI List Now Includes 887 Journals

The Russian Science Citation Index (RSCI) quality assessment and journal selection working group based on Web of Science has completed its updates to the RSCI list. The group particularly considered journals that submitted 219 initiative applications last year. The updated list includes 87 new journals, with 2 journals having been excluded.

Researchers Establish Intracellular Interaction Network in Breast Cancer

HSE University researchers have identified the genes that play a crucial role in breast cancer metastasis. The results of the study were published in the journal PLOS ONE.

Researchers Reveal Genetic Predisposition to Severe COVID-19

HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.

Frontiers Pharmacology magazine published an article «HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons»

A collaborative study by a group of scientists from the International Laboratory for Microphysiological Systems has been published that analyzes the potential benefits and challenges of using HIF prolyl hydroxylase inhibitors as a treatment for COVID-19

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