• A
  • A
  • A
  • ABC
  • ABC
  • ABC
  • А
  • А
  • А
  • А
  • А
Regular version of the site

Laboratory for Research on Molecular Mechanisms of Longevity

Publications
Article
Methods for telomere length measurement: an update on current technologies and emerging approaches

Makarova Julia A., Belova Uliana D., Zvereva M. I. et al.

Frontiers in Molecular Biosciences. 2025. No. 12.

Working paper
Stress Resilience (Proprioceptive and Verbal Individual Differences) in Onco-Patients, Sportsmen and Controls

Liutsko L., Malova Y., Vinokurova E. et al.

public health and health services. 20944. MDPI, 2023

The laboratory conducts research activities in the field of molecular mechanisms of longevity.

Considerable attention in the Laboratory activities is given to sequencing of mRNA, microRNA and assessment of gene methylation. New methodological approaches are being developed for bioinformatic analysis of experimental results, which use mRNA/microRNA sequencing data and graph analysis.

As a part of the Laboratory's work, it is planned to implement a unique approach to influence a controlled multi-organ model with physiological concentrations of metabolites of the intestinal microflora and extracellular vesicles produced by cells of the immune system.

We maintain partnership with the Institute of Bioorganic Chemistry. Academician M.M. Shemyakin and Yu.A. Ovchinnikov RAS, Nizhny Novgorod State University. N.I. Lobachevsky, Scientific Center for Family Health and Human Reproduction.

News

Article by Laboratory Researchers Published in Progress in Lipid Research

An article by laboratory researchers has been published in Progress in Lipid Research (impact factor 14.9), a leading international journal dedicated to research on lipids and metabolism. The paper, “Structure-guided dissection of the genetic variations within human LPA locus and its role in the development of cardiovascular diseases,” examines key genetic factors underlying cardiovascular risk

Review on Modern Telomere Length Measurement Approaches Accepted for Publication in an International Journal ​

A review article by researchers of the Laboratory of Molecular Mechanisms of Longevity on modern approaches to telomere length measurement has been accepted for publication in the journal  Frontiers in Molecular Biosciences

Using Nanopore Sequencing to Analyse Industrial Lactobacillus Strains

The Laboratory for the Study of Molecular Mechanisms of Longevity has put into operation a new portable sequencer, “Nanoporus”, based on nanopore sequencing technology. It enables the acquisition of long DNA and RNA reads without amplification or chemical modification of samples. The first application of the device focuses on decoding the genomes of ten industrial Lactobacillus strains used in cheesemaking, and the resulting data will serve as a basis for de novo assembly of complete genomes and the study of structural variations, expanding the laboratory’s capabilities in genomics, epigenetics and the molecular mechanisms of longevity

Science of Health and Nutrition: New Challenges and Horizons

On 23–24 September, the session “Key Drivers for Building Sustainable Food Systems and Innovative Nutrition Models in the One Health Paradigm” was held at the National Centre “Russia” as part of the 5th International Conference “Quality and Safety of Food Products”. It brought together leading scientists and industry experts. Head of the Laboratory of Molecular Mechanisms of Longevity Maksim Shkurnikov and research fellow Ivan Antipenko delivered a compelling talk on five Lactococcus strains that became the focus of lively discussion.

Predicting Elevated Lipoprotein(a) Levels Using Routine Biochemical Tests: Efficient Screening Based on Medical Data

The Laboratory of Molecular Mechanisms of Longevity at HSE University is developing a method to predict elevated lipoprotein(a) levels based on routine biochemical tests and machine learning. The use of existing medical data will enable the identification of cardiovascular disease risk groups without additional costs, thereby improving early diagnosis and personalized treatment

Young Researchers Investigate the Role of microRNAs in Menopause‑Related Insomnia

Young researchers from the Laboratory of Molecular Mechanisms of Longevity have taken part in a study of the microRNA profile in women with menopause‑related insomnia, identifying significant differences in the level of miR‑412‑5p. This microRNA and its targets may become a promising focus for developing new treatments for sleep disorders during menopause

Staff of the Laboratory for the Study of Molecular Mechanisms of Longevity Take Part in the Conference “Experimental and Computational Approaches to the Study of Pathological Conditions”

The international conference “Experimental and Computational Approaches to the Study of Pathological Conditions” for HSE University students and postgraduates was held on 17 June 2025 at the Faculty of Biology and Biotechnology, HSE University

The staff of the lab, M. Shkurnikov and A. Fatkulin, took part in the XXIV scientific and practical conference with international participation “Innovative trends, scientific achievements and factors of sustainable development of food systems”

The conference was held on December 4-5, 2024 in the FGBNU “FSC  food systems named after V.M. Gorbatov” RAS

The interview with the head of the laboratory was published on the PCR news portal

M.Y. Shkurnikov spoke about the current projects of the laboratory and his vision of research development in the field of microfluidic technologies

The article with the participation of trainee researchers of the laboratory was accepted for publication in the journal ‘Reports of the Academy of Sciences. Life Sciences’

The publication is devoted to the study of proteostasis regulation

More news