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Regular version of the site

Laboratory for Research on Molecular Mechanisms of Longevity

Publications
Article
CD44 variant exons induce chemoresistance by modulating cell death pathways

Yanova M., Stepanova E., Maltseva D. et al.

Frontiers in Cell and Developmental Biology. 2025. Vol. 13.

Working paper
Stress Resilience (Proprioceptive and Verbal Individual Differences) in Onco-Patients, Sportsmen and Controls

Liutsko L., Malova Y., Vinokurova E. et al.

public health and health services. 20944. MDPI, 2023

The laboratory conducts research activities in the field of molecular mechanisms of longevity.

Considerable attention in the Laboratory activities is given to sequencing of mRNA, microRNA and assessment of gene methylation. New methodological approaches are being developed for bioinformatic analysis of experimental results, which use mRNA/microRNA sequencing data and graph analysis.

As a part of the Laboratory's work, it is planned to implement a unique approach to influence a controlled multi-organ model with physiological concentrations of metabolites of the intestinal microflora and extracellular vesicles produced by cells of the immune system.

We maintain partnership with the Institute of Bioorganic Chemistry. Academician M.M. Shemyakin and Yu.A. Ovchinnikov RAS, Nizhny Novgorod State University. N.I. Lobachevsky, Scientific Center for Family Health and Human Reproduction.

News

The staff of the lab, M. Shkurnikov and A. Fatkulin, took part in the XXIV scientific and practical conference with international participation “Innovative trends, scientific achievements and factors of sustainable development of food systems”

The conference was held on December 4-5, 2024 in the FGBNU “FSC  food systems named after V.M. Gorbatov” RAS

The interview with the head of the laboratory was published on the PCR news portal

M.Y. Shkurnikov spoke about the current projects of the laboratory and his vision of research development in the field of microfluidic technologies

The article with the participation of trainee researchers of the laboratory was accepted for publication in the journal ‘Reports of the Academy of Sciences. Life Sciences’

The publication is devoted to the study of proteostasis regulation

D.A. Averinskaya, a member of the Laboratory of Longevity Molecular Mechanisms Research, and M.Y. Shkurnikov, Head of the Laboratory, won the contest of the best Russian-language scientific publications of the National Research University Higher School of Economics

The prize was awarded in the nomination ‘Natural Sciences’

IGFBP6 protein regulates exosome formation

A new paper by the lab team and colleagues has been published in the journal Biochimie

New potential markers for prostate cancer were discovered

MicroRNAs could be an effective alternative to existing markers

A new grant from the Ministry of Education and Science will be awarded to employees of the Laboratory for Research of Molecular Mechanisms of Longevity

Faculty research lab will help protect cheese production from bacterial starter culture pests

Head of the Laboratory of Molecular Mechanisms of Longevity defended his doctoral thesis

M. Shkurnikov's dissertation is devoted to molecular mechanisms of COVID-19 pathogenesis

A publication by HSE biology researchers was included in the top 5 popular articles of PeerJ journal

An article by scientists from the Faculty of Biology and Biotechnology at the National Research University Higher School of Economics has been named among the most frequently read articles published in the journal PeerJ in 2023. In this article, the researchers established a link between genetic features of the human immune system and the ability to effectively resist new waves of COVID-19. PeerJ is a peer-reviewed open access scientific journal covering research in the biological and medical sciences. Each year it ranks the most popular scientific papers.

Hemophagocytic syndrome and macrophages

A seminar dedicated to the study of the molecular biological aspects of the occurrence of hemophagocytic syndrome (HFS) was held in the Laboratory for Research on Molecular Mechanisms of Longevity.

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