Laboratory Staff Participated in a Scientific Conference Organized by the Faculty of Biology and Biotechnology
Four presentations were delivered, focusing on modeling the microenvironment of various body structures and the practical application of these models for studying pathological processes
The conference, titled "Chemotherapy Resistance and Tumor Progression: Approaches to Studying Pathological Conditions," took place on July 11, 2024.
Laboratory staff presented the advancements in 3D liver cell culture and their co-cultivation with immune components. They also shared their results on the HepG2 spheroid cultivation using the "Homunculus" platform. Additionally, they showcased data obtained from the lab on modeling the barrier properties of the placenta to study substance transport under normal and pathological conditions. The goal was to compare the transcriptomes of choriocarcinoma cells under hypoxia-reperfusion and normoxia conditions to investigate preeclampsia.
Experimental solutions for modeling metastases on a chip were also discussed, which will be used to study the organotropism of urothelial cancer metastases. New combinations of silicone components for a pneumatic micropump were proposed to improve the technical characteristics of microchips, resulting in better gas permeability and biocompatibility. This allowed cell culture in flow conditions to extend up to 8 days.