Evgeny Knyazev Presented the Laboratory’s Research Results at the IV Congress of Young Scientists

During the session “Microfluidic Technologies: Will Organ-on-Chip Replace In Vivo Studies?”, Evgeny Knyazev presented the laboratory’s research projects, including:
Development of an in vitro intestine-on-a-chip model with physiologic permeability characteristics;
RSF grant project: Microfluidic placenta-on-a-chip model for the study of preeclampsia.

Microfluidic technologies have emerged as a revolutionary breakthrough in biomedicine, transforming approaches to diagnostics, drug delivery, and cellular analysis. These technologies utilize micro-scale channels to manipulate small fluid volumes, enabling precise control over biochemical reactions and biological interactions.

During the session, key aspects, applications, and the future potential of microfluidic technologies in biomedicine were discussed.

Session Moderator

The session was moderated by Ekaterina Poverennaya, Ph.D. in Biology, Head of the Laboratory at the Orekhovich Research Institute of Biomedical Chemistry.

Speakers

• Evgeny Knyazev, Head of the Laboratory of Molecular Physiology, Faculty of Biology and Biotechnology, HSE University.
• Dmitry Kolesov, Senior Researcher at the Laboratory of Cellular Stress, Institute of General Pathology and Pathophysiology; Senior Researcher at the Laboratory of Biophotonics, Institute of Translational Medicine, Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology; Junior Researcher at the Laboratory of Molecular Physiology, Faculty of Biology and Biotechnology, HSE University; and CEO of LLC “Microfluidic Technologies.”
• Vasily Chernyshov, Head of the Laboratory of Biophotonics, Institute of Translational Medicine, Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology.
• Olga Lazareva, Research Assistant at the Research Institute of Molecular and Cellular Medicine, Medical Institute of the RUDN University; and Trainee Researcher at the Laboratory of Molecular Physiology, Faculty of Biology and Biotechnology, HSE University.

Key Takeaways

The session explored a novel approach to drug testing and modeling pathological processes directly on human cells, potentially even those of individual patients. This approach aims to bypass the costly stage of preclinical testing on laboratory animal models, offering a more efficient and personalized solution for biomedical research.