.jpg "The paper by lab members was published in the highly rated journal Placenta")
The paper by lab members was published in the highly rated journal Placenta
In the article “Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies,” Russian scientists have presented an overview of modern cellular models of preeclampsia—a dangerous pregnancy complication. The study covers two-dimensional and three-dimensional cultures, as well as advanced placenta-on-a-chip microfluidic technologies, allowing the examination of pathological mechanisms at the cellular level. The paper highlights the potential of CRISPR-Cas9 and personalized models for developing new diagnostic and therapeutic methods for preeclampsia. These advancements open prospects for more precise early diagnosis of preeclampsia and the creation of effective treatment strategies.
Evgeny Knyazev Presented the Laboratory’s Research Results at the IV Congress of Young Scientists
During the session “Microfluidic Technologies: Will Organ-on-Chip Replace In Vivo Studies?”, Evgeny Knyazev presented the laboratory’s research projects, including:
Development of an in vitro intestine-on-a-chip model with physiologic permeability characteristics;
RSF grant project: Microfluidic placenta-on-a-chip model for the study of preeclampsia.
Laboratory Staff Participated in a Scientific Conference Organized by the Faculty of Biology and Biotechnology
Four presentations were delivered, focusing on modeling the microenvironment of various body structures and the practical application of these models for studying pathological processes
.jpg "The research from the laboratory was presented at the second Drug Developers Summit \"Sirius.Biotech\"")
The research from the laboratory was presented at the second Drug Developers Summit "Sirius.Biotech"
As part of the special session "Study of Safety and Biomarkers of New Drugs," a report was given on "The Use of the 'Human-on-a-Chip' Platform in Drug Development"
Grant Application by Faculty of Biology and Biotechnology Supported by the Russian Science Foundation
The project to develop a microfluidic placenta-on-a-chip model for studying various aspects of normal and pathological placental physiology, including one of the severe pregnancy complications—preeclampsia—has won in the competition "Conducting Fundamental and Exploratory Scientific Research by Individual Scientific Groups"
Laboratory seminar 'Modeling the biogenesis of SARS-CoV-2'
On November 29, 2022, a workshop on 'Modeling the biogenesis of SARS-CoV-2' was held at the Laboratory of Molecular Physiology
Russian Scientists Investigate the Immune Response to SARS-CoV-2 Variants
HSE University researchers assessed the effectiveness of the T-cell immune response to 11 variants of SARS-CoV-2. Their findings have been published in Nucleic Acids Research.
HSE Researchers Discover Nucleotide Sequence Responsible for Effectively Fighting Pathologies
Researchers from HSE University have discovered nucleotide sequences characteristic of microRNA isoforms (microRNAs with errors). The discovery will help predict errors in microRNA behaviour and create drugs that can detect targets (such as viruses) more effectively. The results of the study have been published in the RNA Biology journal.
Researchers Establish Intracellular Interaction Network in Breast Cancer
HSE University researchers have identified the genes that play a crucial role in breast cancer metastasis. The results of the study were published in the journal PLOS ONE.
.jpg "Researchers Reveal Genetic Predisposition to Severe COVID-19")
Researchers Reveal Genetic Predisposition to Severe COVID-19
HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.