Laboratory Staff Member Presented Report at Conference "Experimental and Informational Approaches to Pathological States Research"

On June 17, the Faculty of Biology and Biotechnology at HSE University hosted the conference "Experimental and Informational Approaches to Pathological States Research." The event featured participation from a laboratory staff member, Olga Chebotareva, a third-year graduate student in Molecular Biology, who presented the report "Microfluidic Modeling of Trophoblast Invasion: An Experimental Approach to Studying Preeclampsia Pathogenesis."

In her presentation, Olga highlighted contemporary challenges in preeclampsia research — a dangerous pregnancy complication leading to high maternal and perinatal mortality. Despite achieved progress in understanding the pathogenesis of this condition, many mechanisms remain unclear, hampering disease diagnosis and prevention.

Special attention in the report was devoted to the upcoming research plan aimed at experimental study of trophoblast invasion mechanisms using microfluidic models. The research utilizes cell lines BeWo b30 (trophoblast model) and EA.hy926 (endothelial model), allowing simulation of processes occurring in a pregnant woman's body. Particular focus is given to modeling hypoxic conditions and adding preeclampsia biomarkers to the culture medium.

Expected results include optimization of microfluidic system parameters for in vitro testing, model validation on clinical samples, and discovery of new biomarkers for early diagnosis. The developed model is also planned for drug screening and creating personalized models with cells from high-risk patients.

The presentation generated significant interest among conference participants, confirming the relevance and promise of the chosen research direction. The obtained results and implemented plan will form the basis for further research and contribute significantly to developing new methods for preeclampsia diagnosis and therapy.