Seminar: gene overexpressionSeminar
On June 24, 2022, the International Laboratory of Microphysiological Systems hosted a joint seminar with the Laboratory for Research on the Molecular Mechanisms of Longevity, dedicated to the issue of miRNA overexpression in human cells, a process that leads to an excess amount of transcript produced by the genome.
In vivo, gene overexpression occurs because of a violation of the «reading» of information from the genome, which, in turn, can lead to phenotypic changes or the development of diseases, in particular, cancerous tumors. However, the overactivity of certain genes is also used as a therapy and can be induced artificially through the introduction of an altered gene.
Thus, within the framework of the seminar, microRNA candidates for achieving overexpression and variants of lentiviral vectors used in the delivery of genetic material into the cell to obtain stable lines with constant overexpression were considered.
The head of the International Laboratory of Microphysiological Systems Diana Maltseva and the head of the Laboratory for Research on Molecular Mechanisms of Longevity Maksim Shkurnikov, as well as laboratory staff spoke at the seminar.