Tag "publications"

Researchers at the Molecular Physiology Laboratory of HSE University presented results of a multidisciplinary investigation into preeclampsia, correlating single-cell sequencing data from placental tissue in early-onset preeclampsia with experimental hypoxia induction in cell models. For the first time, gene expression profiles in diseased placental samples were directly compared to the molecular response of trophoblasts subjected to chemical hypoxia induction using a novel oxyquinoline derivative.

The official HSE University website has published an article titled "New Models for Disease Research: From Petri Dish to Organs-on-a-Chip," focusing on the work of the Molecular Physiology Laboratory at the Faculty of Biology and Biotechnology in developing innovative approaches to organ-on-chip modeling and researching preeclampsia — one of the most dangerous pregnancy complications.

In the article “Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies,” Russian scientists have presented an overview of modern cellular models of preeclampsia—a dangerous pregnancy complication. The study covers two-dimensional and three-dimensional cultures, as well as advanced placenta-on-a-chip microfluidic technologies, allowing the examination of pathological mechanisms at the cellular level. The paper highlights the potential of CRISPR-Cas9 and personalized models for developing new diagnostic and therapeutic methods for preeclampsia. These advancements open prospects for more precise early diagnosis of preeclampsia and the creation of effective treatment strategies.

The textbook titled “Professional Training Internship: Year 1 – A Practical Guide for Students and Educators” by Knyazev E.N. and Chebotareva O.E. has been honored in HSE University's academic achievement awards for its contribution to the institution’s reputation (Level 2).

Leading scientists from HSE University have won the Scientific Category of the 2024 Best Russian-Language Scientific and Popular Science Works Competition by HSE University employees in the "Biology and Medicine" section for their research on predicting the effectiveness of chemotherapy with gemcitabine in patients with bladder cancer.

On November 29, 2022, a workshop on 'Modeling the biogenesis of SARS-CoV-2' was held at the Laboratory of Molecular Physiology

HSE University researchers assessed the effectiveness of the T-cell immune response to 11 variants of SARS-CoV-2. Their findings have been published in Nucleic Acids Research.

An international team of researchers including Alexander Tonevitsky, Professor at HSE’s Faculty of Biology and Biotechnology, found that pituitary hormones may produce different effects on the left and right sides of the body following a traumatic brain injury. These differences can accelerate the development of motor disorders. Researchers are trying to determine whether treatment that blocks the corresponding hormones can counteract these effects. The results of the study were published in the journal eLife.

Researchers from HSE University have discovered nucleotide sequences characteristic of microRNA isoforms (microRNAs with errors). The discovery will help predict errors in microRNA behaviour and create drugs that can detect targets (such as viruses) more effectively. The results of the study have been published in the RNA Biology journal.

HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.